He says he has no regrets turning down the role of McDreamy on Grey's Anatomy. He wrote about turning down the job in his 2014 memoir. It recently came back up when he was on the podcast, WTF with Marc Maron. He said it probably cost him $70 million dollars but that it was "just money." He said when they started calling Patrick Demsey, "McDreamy" he knew the role was not for him.
Could you see Rob Lowe as McDreamy?